NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which medication is not a CYP-2D6 substrate?

Methadone
Fluoxetine
Tamoxifen
Methamphetamine

The correct answer is: Fluoxetine

Fluoxetine is the correct answer. Fluoxetine is primarily metabolized by CYP2D6, making it a CYP2D6 substrate. Therefore, it is not the medication that is not a CYP2D6 substrate. Methadone, tamoxifen, and methamphetamine are all substrates of CYP2D6. Methadone is metabolized by CYP2D6 into its active metabolite, tamoxifen is converted to its active metabolite endoxifen by CYP2D6, and methamphetamine is also metabolized by CYP2D6.