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Tumor Lysis Syndrome (TLS) is a serious condition that can occur when cancer cells break down quickly and release large amounts of waste products into the bloodstream. This can cause severe electrolyte imbalances and other complications. The first line treatment for TLS is Allopurinol, which is a medication commonly used to prevent high levels of uric acid in the blood. This helps to prevent uric acid crystals from forming in the kidneys, which can lead to kidney damage. Rasburicase (B) is also an effective treatment for TLS, but it is typically used in more severe cases or as a second line treatment. Hydration alone (C) is not enough to effectively manage TLS, as it does not address the underlying issue of elevated uric acid levels. Allantoin (D) is not a recommended treatment for TLS and does not have any proven benefits in managing this condition.