NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which medication is frequently associated with Cytokine Release Syndrome (CRS) when administered?

Zoledronic acid
Monoclonal Antibodies (MAb)
Capecitabine
Nabilone

The correct answer is: Monoclonal Antibodies (MAb)

Monoclonal Antibodies (MAb) are often associated with Cytokine Release Syndrome (CRS) due to their mechanism of action. When administered, MAb can bind to specific targets on cells, resulting in the release of cytokines in the body. This can lead to symptoms such as fever, fatigue, and muscle pain, which are all characteristic of CRS. Zoledronic acid, Capecitabine, and Nabilone are not typically associated with CRS, as their mechanisms of action do not involve the release of cytokines. Therefore, these options are incorrect.