NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which malaria prophylaxis is most effective against P. vivax?

  1. Doxycycline (Doryx, vibramycin)

  2. Atovaquone/proguanil (malarone)

  3. Primaquine

  4. Chloroquine

The correct answer is: Primaquine

Primaquine is the most effective prophylaxis against P. vivax, as it specifically targets the dormant liver forms of the parasite, which are responsible for relapses. Doxycycline is a good option for prophylaxis against P. falciparum, but is not as effective against P. vivax. Atovaquone/proguanil is also effective against P. falciparum, but not as effective against P. vivax. Chloroquine is not recommended for prophylaxis against any type of malaria anymore due to widespread resistance.

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