NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which action does NOT describe a function of Triptans in migraine treatment?

  1. Increase blood pressure

  2. Cause vasoconstriction

  3. Act as a selective agonist for the 5-HT2 receptor

  4. Contraindicated with MAOIs

The correct answer is: Act as a selective agonist for the 5-HT2 receptor

Triptans are a class of drugs used in the treatment of migraines. They work by constricting the blood vessels in the brain, which helps to reduce the pain and other symptoms associated with migraines. Options A and D are incorrect because both describe actions that are known functions of Triptans in migraine treatment. Triptans can increase blood pressure, and they should not be taken with MAOIs (a type of antidepressant) due to potential interactions and serious side effects. Option B may seem like a potential answer, but it is actually incorrect. Vasoconstriction is the main mechanism of action for Triptans and is essential in treating migraines. Without this action, Triptans would not be effective in reducing symptoms. Therefore, option C is the correct answer as it does not accurately describe a function of Triptans in migraine treatment. They do act as selective agonists for the 5-HT2 receptor, which is responsible for regulating serotonin levels in the brain. However, this is not the primary function of Triptans in migraine treatment.