NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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When converting NPH BID to Lantus or Basaglar daily, you should use what percentage of NPH dose?

50%
60%
80%
100%

The correct answer is: 80%

When converting NPH BID (twice a day) dosing to Lantus or Basaglar daily dosing, you should use about 80% of the total daily NPH dose. This is because Lantus and Basaglar provide more consistent basal insulin coverage over a 24-hour period compared to NPH which has a peak action. By using 80% of the NPH dose, you are adjusting for the differences in the pharmacokinetics of the two insulins while ensuring adequate coverage. Options A, B, and D are incorrect because using these percentages could result in inadequate or excessive insulin coverage, leading to potential hypoglycemia or hyperglycemia.