NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What type of organisms does Aztreonam (Monobactams) primarily target?

  1. Gram positives

  2. Gram negatives

  3. Anaerobes

  4. Atypicals

The correct answer is: Gram negatives

Aztreonam is a monobactam antibiotic that primarily targets Gram-negative bacteria. Monobactams, like aztreonam, have a unique structure that allows them to specifically target and inhibit the growth of Gram-negative bacteria by binding to penicillin-binding proteins (PBPs) on the bacterial cell wall. This antibiotic is particularly effective against a wide range of Gram-negative pathogens, including Pseudomonas aeruginosa, Escherichia coli, Klebsiella species, and Haemophilus influenzae. Therefore, the correct answer is B, Gram negatives. Gram positives (Choice A) are not the primary target of aztreonam. Anaerobes (Choice C) are not typically targeted by aztreonam. Atypicals (Choice D) refer to bacteria such as Mycoplasma, Chlamydia, and Legionella, which are not the primary focus of aztreonam's activity.

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