NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What must Androgen biosynthesis inhibitors like Abiraterone be coadministered with?

GnRH agonists
Prednisone
Calcium supplements
Vitamin D

The correct answer is: Prednisone

Abiraterone is a medication used for the treatment of prostate cancer. It is an androgen biosynthesis inhibitor, which means it blocks the production of androgen hormones in the body. In order for it to be effective, it must be taken with prednisone, a steroid medication. This is because Abiraterone can cause a rise in certain hormones in the body, which can lead to unpleasant side effects like high blood pressure and fluid retention. Prednisone helps to counteract these effects and make Abiraterone more effective in treating prostate cancer. It is important to note that while GnRH agonists (A) may also be used in the treatment of prostate cancer, they are not necessary for the effectiveness of Abiraterone. Supplements like calcium (C) and vitamin D (D) may be important for overall health, but they are not needed to coadminister with Abiraterone.