NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is the first line treatment for osteoporosis in most patients?

Calcitonin
RANKL Inhibitor
Bisphosphonates
Parathyroid hormone 1-34

The correct answer is: Bisphosphonates

The first-line treatment for osteoporosis in most patients is bisphosphonates (Choice C). Bisphosphonates are commonly prescribed due to their ability to inhibit bone resorption, thereby helping to prevent further bone loss and reduce the risk of fractures. They are generally well-tolerated and have been shown to be effective in increasing bone mineral density and reducing fracture risk in patients with osteoporosis. Additionally, bisphosphonates have a long-standing history of use and a robust body of evidence supporting their efficacy in the treatment of osteoporosis.