NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is the first line treatment for antianginal in SIHD?

Nitrates
Calcium channel blockers
Ranolazine
Beta-blockers

The correct answer is: Beta-blockers

Beta-blockers are considered the first-line treatment for stable ischemic heart disease (SIHD) due to their ability to reduce myocardial oxygen demand by decreasing heart rate, blood pressure, and contractility. They also improve exercise tolerance and reduce the frequency of angina episodes. Nitrates, calcium channel blockers, and ranolazine may also be used in the management of SIHD, but beta-blockers are typically chosen as initial therapy due to their demonstrated benefits in reducing mortality and the risk of recurrent myocardial infarction in this patient population.