NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is contraindicated with the use of anticholinergics for OAB?

Narrow angle glaucoma
Hypertension
Diabetes
Hyperlipidemia

The correct answer is: Narrow angle glaucoma

Anticholinergics are commonly used to treat overactive bladder (OAB) by blocking the action of acetylcholine on cholinergic receptors in the bladder, reducing involuntary bladder contractions. One of the major side effects of anticholinergics is their potential to cause pupil dilation and increase intraocular pressure, which can be dangerous in patients with narrow-angle glaucoma due to the risk of acute angle-closure glaucoma crisis. Therefore, anticholinergics are contraindicated in patients with narrow-angle glaucoma due to the potential to exacerbate the condition and lead to severe complications. Options B, C, and D are not contraindications for the use of anticholinergics in OAB treatment, making them incorrect choices.