NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is a unique warning or adverse effect associated with Oritavancin?

Should not be used in osteomyelitis
QT prolongation
Should not be mixed with dextrose
Increased risk of C. diff

The correct answer is: Should not be used in osteomyelitis

Oritavancin is an antibiotic used to treat infections. It is a lipoglycopeptide antibiotic, which is a class of antibiotics that work by disrupting the cell wall of bacteria. This disruption can lead to certain adverse effects, such as QT prolongation and increased risk of C. diff, which are common with this type of antibiotic. However, what makes Oritavancin unique is that it should be avoided in patients with osteomyelitis, a bone infection. This is because Oritavancin has poor penetration into bone, thus making it ineffective for treating osteomyelitis. Therefore, the correct answer is A. The other options, B, C, and D, are all possible adverse effects or drug interactions with Oritavancin, but they are not unique to this medication.