NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is a side effect of 5-alpha reductase inhibitors?

Increased libido
Nasal congestion
Ejaculation disturbances
Hypertension

The correct answer is: Ejaculation disturbances

5-alpha reductase inhibitors are commonly prescribed for the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness. These medications work by blocking the conversion of testosterone to dihydrotestosterone (DHT), a hormone that can contribute to prostate enlargement and hair loss. However, in doing so, they may also cause various side effects, such as ejaculation disturbances. This can include decreased semen volume, decreased ejaculate force, and in some cases, difficulty achieving or maintaining an erection. Increased libido (choice A) and nasal congestion (choice B) are not known side effects of 5-alpha reductase inhibitors. Hypertension (choice D) is typically not associated with this type of medication, but it is possible for individuals with underlying cardiovascular issues to experience changes in blood pressure while taking these medications. However, this is not a common side effect and is not directly caused by the medication's mechanism of action. Overall, ejaculation disturbances (choice C) are the most widely reported side effect of 5-alpha reductase inhibitors and should be discussed with a healthcare provider if experienced.