NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is a common side effect of Cyclophosphamide and Ifosfamide due to the metabolite acrolein?

Hypertension
QT prolongation
Hemorrhagic cystitis
Osteoporosis

The correct answer is: Hemorrhagic cystitis

An acrolein is one of the metabolites of Cyclophosphamide and Ifosfamide that can cause oxidative stress and damage to the bladder, leading to inflammation and hemorrhagic cystitis. Therefore, this is a common side effect of these drugs. Hypertension, QT prolongation, and osteoporosis are not related to the metabolite acrolein and are not commonly associated with these drugs.