NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What common adverse effect is shared by both prostacyclin analogues and endothelin receptor antagonists in the treatment of PAH?

  1. Hepatotoxicity

  2. Hypotension

  3. Headache

  4. Jaw pain

The correct answer is: Headache

Both prostacyclin analogues and endothelin receptor antagonists are commonly used in the treatment of pulmonary arterial hypertension (PAH). A common adverse effect shared by both of these drug classes is headache. This side effect is often reported by patients taking these medications and can sometimes be severe enough to prompt dose adjustments or changes in therapy. Monitoring for headache and managing it appropriately is important during the treatment of PAH.

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