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Potassium oral supplements can often cause gastrointestinal (GI) upset, which can include symptoms like nausea or stomach discomfort. Taking potassium supplements with a full glass of water and food is recommended to help reduce the likelihood of experiencing GI upset. Water can help ensure proper absorption of the potassium supplement, while taking it with food can help buffer the stomach and minimize any potential irritation that the supplement may cause. Therefore, option A is the correct choice in this scenario. Taking potassium supplements on an empty stomach (option B) might increase the likelihood of experiencing GI upset. Similarly, taking them with only a small amount of liquid (option C) may not provide enough hydration for proper absorption. Lastly, taking potassium supplements without any liquid (option D) is not recommended as sufficient fluid intake is essential for the proper functioning of potassium in the body.