NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

Consumption or administration of Methotrexate can often lead to several side-effects such as bone marrow suppression, mucositis, and cytotoxicity. However, when Methotrexate is administered with Leucovorin, the toxic effects can be significantly reduced. Leucovorin is a form of folic acid that helps to protect healthy cells in the body from the damaging effects of Methotrexate, making it the best option for co-administration. Ethyol (A) is a drug that is used to prevent or lessen certain side effects caused by cancer medicines. However, it may not be as effective in reducing Methotrexate's toxicity as Leucovorin. Dexrazoxane (C) is used to prevent or reduce heart-related side effects that may occur during treatment with certain chemotherapy drugs. Although it has been found to be effective in reducing toxicity of other chemotherapy drugs, there is not enough evidence to suggest that it can reduce Methotrexate's toxicity when co-administered. Uridine triacetate (D) is used as an antidote to treat accidental overdose or life-threatening toxicities caused by chemotherapy drugs, including Methotrexate. However, it