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Both Venlafaxine and Duloxetine are commonly used as antidepressants in the treatment of depression. They are both classified as serotonin-norepinephrine reuptake inhibitors (SNRIs), which work by increasing the levels of serotonin and norepinephrine in the brain, thus improving mood and reducing symptoms of depression. These medications are not typically used for insomnia, epilepsy, or high blood pressure.