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MAOIs (Monoamine oxidase inhibitors) are a group of medications that are known to interact with a wide variety of drugs, foods, and substances. One of the most serious warnings associated with MAOIs is the potential for dangerous drug-drug interactions (DDIs). This is because MAOIs can inhibit the breakdown of certain neurotransmitters in the brain, leading to excess levels that can cause a hypertensive crisis when combined with other medications or foods containing tyramine. These interactions can be life-threatening and therefore require close monitoring and patient education. This is why option C is the correct choice, as it specifically mentions DDIs and hypertensive crisis, which are significant warnings associated with MAOIs.