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Question: 1 / 1820

Which medication is a MEK 1 and 2 inhibitor used in combination with BRAF inhibitors?

Cobimetinib (Cotellic)

Cobimetinib (Cotellic) is the correct answer. It is a MEK 1 and 2 inhibitor used in combination with BRAF inhibitors to treat certain types of cancer, such as melanoma. MEK inhibitors inhibit the MEK enzymes in the MAPK/ERK pathway, which is dysregulated in cancer cells. By combining a MEK inhibitor like cobimetinib with a BRAF inhibitor, it can lead to improved outcomes in patients with BRAF-mutant melanoma.

The other options are incorrect:

- Afatinib (Gilotrif) is a tyrosine kinase inhibitor used for the treatment of non-small cell lung cancer.

- Alectinib (Alecensa) is also a tyrosine kinase inhibitor used for the treatment of non-small cell lung cancer.

- Dabrafenib (Tafinlar) is a BRAF inhibitor used alone or in combination with trametinib (a MEK inhibitor) for the treatment of melanoma and other cancers with BRAF V600E mutations.

Get further explanation with Examzify DeepDiveBeta

Afatinib (Gilotrif)

Alectinib (Alecensa)

Dabrafenib (Tafinlar)

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